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Hypomorph mutations or knockdown of many cohesin genes (SMC1, SMC3, RAD21/SCC1, STAG2) are synthetic lethal with PARPi olaparib which are attributed to the overlapping role of cohesin and PARP1/2 in preventing replication fork collapse (Liu et al, 2018

Metformin induces cell cycle arrest and apoptosis in drug-resistant leukemia cells

Instead, by supporting GI tract integrity, it may help reduce one of the upstream drivers of autoimmune activation

doi: 10.1126/scitranslmed.3003763 40 JiangQZhaoSLiuJBSongLLWangZGDingBQ

Figure 1 The BBB is composed of specialized brain endothelial cells and astrocyte end feet that form contacts with the endothelial cells