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A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem One question. One concept. One point on exam day. Acetaminophen overdose? You should recognize the antidote in seconds, not after rereading a textbook. Train your brain with active recall and build Nishith Revappala Chronic alcoholism lowers the threshold for acetaminophen toxicity. Swipe to know about the metabolism of acetaminophen and how chronic Instagram

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