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Two-way ANOVA with Tukeys multiple-comparison test

Similarly, dissolving microneedles (DMNs) for allopurinol delivery demonstrate sustained SU reduction in animal models, avoiding gastrointestinal toxicity (Singh et al., 2017)

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This metabolized marker AITC-NAC suggested low exposure in T2D compared to healthy mice

First-line systemic therapies like methotrexate (MTX), cyclosporine A (CyA), and retinoic acid are effective but can induce adverse effects such as hypertension, hepatotoxicity, and renal impairment