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These models provide complementary insights into the pathophysiology of AD, highlighting the distinct temporal and biochemical dynamics of amyloid pathology and cognitive decline

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In the United States alone, unpaid caregiving costs were estimated at $271 billion in 2021, underscoring the urgency of developing cost-effective treatments that not only alleviate symptoms but also slow disease progression ( 4.5 The promise of natural compound in AD therapy Natural compounds have garnered significant attention for their multi-targeting properties, low toxicity, and long-standing use in traditional medicine

These mechanisms are complementary

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