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Ekins S, Mankowski DC, Hoover DJ, Lawton MP, Treadway JL, Harwood HJ Jr

As the only bifunctional enzyme in the ARS family, EPRS activates the WNT/GSK-3/-catenin signaling pathway and stimulates the accumulation of -catenin in the nucleus by directly binding to SCYL2 (SCY1-like protein 2), promoting cancer cell proliferation

36 On the basis of this marker, a chimeric peptide, E16-uPA24, that specifically targets senescent cells was constructed

Notably, in RagA/B double-knockout cardiomyocytes that show impaired lysosomal function, phosphorylation of mTORC1 substrates, such as 4E-BP1, is not significantly affected (Kim et al., 2014)

Mitochondrial regulation in stem cells