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4 Oral melanoacanthoma is another melanotic lesion that should be differentiated from other intraoral pigmented lesions

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In some people, especially those with light skin, a change in the shape of moles, new moles, and skin cancer, have all occurred in people using melanotan

Pigmentary incontinence may be present.1-3 Diagnoses of hyperpigmented lesions of the oral mucosa include physiologic melanin pigmentation, drug-induced skin pigmentation, oral melanocytic nevus, melanoma, black hairy tongue, oral melanoacanthoma, smokers melanosis, amalgam tattoo, postinflammatory hyperchromia, and Laugier-Hunziker syndrome (pigmentation of the oral mucosa associated with melanonychia)

they are usually localized on the lip, gingiva, palate or buccal mucosa