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Neither has a pharmaceutical formulation, standardized purity requirements, or GMP manufacturing standards commonly applied to approved drugs

Pickart, The Human Tri-Peptide GHK and Tissue Remodeling, J

Sterility must be maintained at each stage

Across those trials the compound's tolerability was reported as comparable to placebo, with no statistically significant effects detected on serum IGF-1, fasting glucose, insulin, HbA1c, cortisol, or thyroid hormones at the levels studied, and no serious adverse events attributed to the compound [7]

Starting at lower doses and increasing gradually reduces the likelihood of systemic effects