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Garey, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Taken together, these observations suggest that except in vitamin B 12 deficiency (which only responds to cyanocobalamin treatment because of the inactivation of methionine synthase), folate treatment should be the most adequate therapy to reverse hyperhomocysteinemia detected both under basal conditions and after an oral methionine load

The downstream normalization of nitric oxide and cytokine output may then secondarily interact with neighboring hepatocytes in cell cultures, including their IGF-I expression

For example, recent studies showed a relationship between rs12201199 in thiopurine S-methyltransferase gene ( TPMT ) and rs9332377 in the catechol-O-methyltransferase gene ( COMPT ) with cisplatin-induced hearing loss in children (Ross et al., 2009)