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In the kainate and pilocarpine rat experimental models of TLE, ROS production through NOX activity is associated with microglial activation and is responsible for neurodegeneration in these models (Patel et al., 2005

Jain AK, Jaiswal AK

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More than 44,000 people end up in the emergency room and four hundred people die in the U.S

For example, the collagen IV NC1 domain fragments canstatin (Kamphaus et al., 2000) and arresten (Nyberg et al., 2008) are anti-angiogenic, tumour suppressive and able to regulate apoptosis