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Cyclic dimeric guanosine monophosphate (c-di-GMP) is an ubiquitous second messenger found in many prokaryotes such as Mycobacterium tuberculosis, Vibrio cholerae , or Salmonella enterica that regulates a wide span of physiological processes including bacterial protein secretion, multicellular behaviour, virulence, motility, and cell development and differentiation [112,113]

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In addition, a meta- analysis of retrospective and prospective trials, involving both Caucasians and Asians, confirmed higher NLR in PD patients than in controls (Hosseini et al., 2023)

If it can accelerate tendon healing even modestly, it could transform recovery timelines for millions of athletes and injured people