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We have checked the level of cellular ROS and GSH as well as NO, TNF-, IL-6, glutamate and cystine concentration in the microglial culture supernatant to find out the probable factor responsible for bystander neuronal death

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1) is one of 20 naturally occurring, 'biogenic' amino acids which linked by peptide bonds form polypeptides and proteins

Collectively, this work proposes an LDH-based strategy that concurrently alleviates pathological acidosis, oxidative stress, mitochondrial dysfunction, and macrophage polarization imbalance, providing a potential nanotherapeutic approach for OA management