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Biol Trace Elem Res (2005) 104:416

VIP is generally well tolerated under strict medical supervision, with mild and temporary effects such as facial flushing, lightheadedness or nasal irritation when using intranasal formulations

Although various drugs and compounds have been listed that can target the MET channel to alleviate ototoxicity caused by cisplatin or aminoglycosides, most of these compounds, such as d-Tubocurarine, Phenoxybenzamine, and Carvedilol, not only fail to provide ear protection at high concentrations but also enhance ototoxicity, with a narrow effective dose window limiting the practical clinical application of many MET channel blockers

To find out the structural divergence/similarity in generated models, the structures were superposed to calculate the percentage of structural overlap and RMSD values (Table 4)

Results: WT mice on Chow showed no noticeable abnormalities