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b) the widespread use of antibiotics in animal farming, which impairs B12 production by the animal gut microbiota

Qushi Huayu Decoction reduces liver injury in NASH by suppressing the MAPK pathway to protect the colonic tight junction and alters serum lipids by regulating the gut microbiota, including Bacteroides, Blautia, Lachnoclostridium and Turicibacter [157, 158]

However, after 24 h, the ATP production in HEB cells gradually decreased under the influence of metformin and simvastatin, showing little difference from the control group