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The review was conducted under Project Orbis, the FDAs framework for concurrent international oncology review, alongside partner agencies from Australia, Brazil, Canada, Singapore, and Switzerland

Musculoskeletal improvements in strength, range of motion, and pain reduction typically follow over weeks 3 through 6

Reported therapeutic strategies include lymphotoxin -receptor signaling agonists (TNFSF14), activating -catenin pathways, and CD73 blockers (260262)

This study was approved by the Ethic Committee of School of Medicine, University of Zagreb (Project code: 380-59-10106-17-1001290

The monomeric scFv16 and Nb35 were prepared as previously reported 28,31