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Liver biopsies from MASH patients and M1 macrophage with the PNPLA3 I148M variant revealed reduced PGC1-alpha, NRF1/2, mt-ND1, and 16sRNA mRNA transcripts compared to wildtype

The activation of EMT factors has been widely studied and a remarkably complex picture has emerged with links to microenvironmental signals, oncogenic signalling pathways, epigenetic factors such as DNA methylation, metabolism and post-transcriptional regulation