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Besides MLH1 , which is often mutated or downregulated in the context of CDDP resistance, 126, 127, 128, 129 these genes include Rho GDP dissociation inhibitor beta ( ARHGDIB ), armadillo repeat containing, X-linked 2 ( ARMCX2 ), collagen, type I, 1 ( COL1A1 ), filamin A ( FLNA ) filamin C ( FLNC ), mesoderm-specific transcript ( MEST ), neurotensin ( NTS ) and proteasome (prosome, macropain) subunit, type, 9 ( PSMB9 ), pointing to the existence of hitherto unexplored mechanisms whereby malignant cells can lose their sensitivity to CDDP

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KS: Conceptualization, Data curation, Investigation, Writing review & editing

5 Modern colorimetric detection methods are rapid, sensitive, portable, and affordable, thus making the sensing process available for various scenarios including clinical laboratories, 6 industrial environments, 7 agricultural areas, 8 residential spaces, 9 and public transit systems

Int J Dev Neurosci 27:599605 Khedr LH, Rahmo RM, Eldemerdash OM, Helmy EM, Ramzy FA, Lotfy GH, Zakaria HA, Gad MM, Youhanna MM, Samaan MH (2024) Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive impairment