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doi: 10.3390/biomedicines8070206

IGF-1 LR3 activates the same downstream signaling cascades as native IGF-1, including PI3K/Akt and MAPK/ERK pathways, which are central to cell growth, proliferation, and survival

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Furthermore, gut microbiome involvement in rosacea needs to be clarified, despite several studies proposing a correlation between Helicobacter pylori and rosacea as treatment with fecal-derived oral probiotics ameliorated rosacea symptoms in a rosacea mouse model [43]

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