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interstitial fibrosis and residual restrictive pulmonary diseases may be developed [28]

Bixin There has been an increasing focus on bixin, an FDA-approved natural food colourant from the seeds of the achiote tree ( Bixa orellana L.) native to tropical America [209, 221, 227]

identified a small chemical compound, erastin, by using synthetic lethal high-throughput screening, which can cause selectively toxic to cancer cells expressing oncogenic RAS, but not wild-type cells in a manner different from traditional apoptosis (Yang and Stockwell, 2008)

Yes, start with low concentrations and patch-test first

NCI concluded that the data demonstrated no benefit.[2] In 1972, the American Cancer Society (ACS) published a statement summarizing the negative assessments of Gerson's treatment.[10] Another statement published by ACS in 1991 concerned various "metabolic therapies" (defined as treatments that depend on changing metabolism through diet, enemas, and supplements given at clinics in Tijuana, Mexico) and reemphasized the lack of scientific evidence on the efficacy of the Gerson regimen.[11] Gerson died in 1959, leaving behind no systematic way to continue offering his treatment