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Aging 12, 98829914

In addition to GSH, cysteine metabolism produces reactive sulfur species such as hydrogen polysulfides (H 2 S n ), which can act as nucleophilic and redox-active metabolites scavenging reactive oxygen species and lipid peroxyl radicals, thereby mitigating lipid peroxidation independently of the GPX4GSH axis [77,78]

Neurotransmitter Regulation: NAC assists in the regulation of glutamate, a neurotransmitter responsible for transmitting signals between the brain and nerves

Ultimately, these mechanistic benefits play out in clinical trials, where ALCAR supplementation has been shown to improve cognitive function and slow neurodegeneration [22]

reported that iron homeostasis in mitochondria caused by frataxin deficiency can aggravate oxidative stress in T2DM patients [68]