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Furthermore, probiotics modulate oxidative equilibrium by modulating antioxidant signaling pathways, with antioxidant effects exerted via the Nrf2, SIRT1, MAPK, and PKC pathways, demonstrating strain specificity (134)

The tripeptid glutathione, as the main antioxidant in the brain, is needed for the conversion of methylglyoxal, a toxic by-product of metabolism, into d-lactate by glyoxalase 1 (EC 4.4.1.5) [94,95]