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They trigger an inflammatory response that activates macrophages and neutrophils ( and H 2 O 2 during the pathogenesis of endometriosis ( and H 2 O 2 produced by these inflammatory responses in the peritoneal, ovarian and oviductal environments of endometriomal implants are significantly higher than those which are generally encountered in their healthy counterparts ( Pernicious effects of refluxed blood and the balance of pro-oxidant and antioxidant forces: the fenton reaction In addition to inflammatory components, accumulated refluxed menstrual blood contains numerous lysed erythrocytes

Cell and Tissue Research Nov 2008;334(2):179-185

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Nucleic acids Res

Mitochondrial dysfunction Mitochondria in neurons are responsible for fueling neuronal cells and regulating a myriad of molecular mechanisms, including calcium modulation, lipid metabolism, and intracellular ROS production [36, 82]