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PX-12 achieves a reduction in TXN1 activity either by covalently binding to the key cysteine residue Cys73 in TXN1 or by enhancing the dimerization of its oxidized form [225]

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In the setting of high ROS, as is seen with G6PD-inhibition, heme production has been shown to be impaired 137

Parallel to identification of Mn neurotoxic properties, neuroprotective strategies have been reported, and these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols and non-characterized components), iron chelating agents, precursors of glutathione (GSH), and synthetic compounds that can experimentally afford protection against Mn-induced neurotoxicity

One of the most important defense we have against any disease is our gut microbiome, which is constantly assaulted by a range of toxins, parasites, bacteria and fungi that we inevitably ingest