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Indeed, P-15 was found to stimulate the proliferation and differentiation rate as well as the growth factor production of osteoblasts in vitro [113, 137, 189]

The most common polymorphisms are SCNA and LRRK2, which were confirmed as risk factors for disease (Ozansoy and Baak, Figure 1)

Khorsandi K, Hosseinzadeh R, Sadat Esfahani H, Keyvani-Ghamsari S, Ur Rahman S

Importantly, even the integrity of BBB can vary among PD patients, altering permeability of therapeutic agents and further complicating the development of effective PLGA nanoparticle therapies 145,146