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Ultimately, this leads to an OXPHOS reaction, providing energy for the organism

10.1016/j.neurobiolaging.2015.02.016 Neurobiol

Tsai and Coyle, 1995), the observed increase may reflect higher neuronal viability and, therefore, possibly higher insular activity, further supporting the aforementioned theory

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Three-dimensional (3D) brain organoids are formed from a mixture of human iPSCs-derived neurons and glial cells cultured using artificial matrices that resemble the extracellular matrix (e.g., matrigel) and can mature in a more physiologically relevant microenvironment, closely mimicking the complexity of cellular interactions in the brain