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Cls treatment significantly reduced ethanol-induced upregulation of the pro-inflammatory markers (IL-1, IL-6, TNF-, and NF-B), MDA (a marker of lipid peroxidation), and caspase-3 and cleaved caspase-3 (apoptotic markers)

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Moreover, zinc inhibits superoxide generation in peritoneal neutrophils at concentrations as low as 10 M [151], while other studies report enhanced superoxide release and hydrogen peroxide production at higher zinc concentrations [152]

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