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doi: 10.1016/j.carbpol.2017.04.066

There is not a strict connection between concentrations of PM and depletion of AA and GSH

The primary contributors to ROS production reside in the mitochondria, which supply over 90% of cellular ROS ( 2 - ) is generated through reactions catalyzed by complex I, II and III ( 2 O 2 ), which can freely diffuse into the cytosol ( Another important source of ROS in T cells is the family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, including NOX2 and DUOX2

Devoid of the multi-layered smooth muscle and elastic fibers characteristic of normal vessels, these abnormal vessels not only fail to effectively alleviate hypoxia but exacerbate tissue edema through increased vascular leakage