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2.2.4 Homologous recombination screening Before proceeding with in vitro and in vivo experiments, the gene knockouts were confirmed

Garca-Santisteban, V

Buckingham, E

10.1111/cpr.13448 182 WeiJ

Problems in the use of flavonoids in high doses for a long time can arise from the possible interaction with the main drug transporters (and metabolizing enzymes), leading to alterations in the pharmacokinetics of substrate drugs and, therefore, to their efficacy and toxicity [102]