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Symptoms can include fatigue, weakness, numbness or tingling in the hands and feet, difficulty walking, memory issues, and anemia

3 Some physicians may treat using high amounts of oral B12 4 , intranasal B12 4A, or sublingual B12

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In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing