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Emerging evidence suggests that A plaques contribute synergistically to disease progression together with oxidative stress, inflammation and mitochondrial dysfunction, while this is less clear in regards to tau pathology (Roy et al., 2023), since A aggregation has been determined as source of oxidative stress (Karapetyan et al., 2022) and oxidative stress has been shown to increase the aggregation of A (Mandal et al., 2022)

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The authors suggest empowering primary care clinicians to discuss interventions with the treating oncologist and/or a clinician trained in pain medicine, as they are well suited for a role as first-line patient advocates and may be able to help support quality-of-life measures.