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With the exception of the poorly active hybrid protein ScGrx8 from yeast 11 , the second cysteine residue of enzymatically active Grx is dispensable for the reduction of glutathionylated substrates and the low-molecular weight model substrate bis(2-hydroxyethyl)disulfide (HEDS) 15,16,17,18,19,20,21,22,23,24,25

Supplementary material The Supplementary Material for this article can be found online at: References 1 VangapanduHVHavranekOAyresMLKaipparettuBABalakrishnanKWierdaWGet al

Unlike many antioxidants that we get from food and supplements, glutathione is actually produced in the body from three precursor amino acidscysteine, glycine, and glutamine (1)

Hum Reprod (2007) 22(1):1749

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