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Polyneuropathy with lipid deposits in Schwann cells and axonal degeneration in cerebrotendinous xanthomatosis

due to lack of oxygen before or during birth, various congenital disorders which interfere with brain development, etc

A protocol is only as good as the compound it's delivering

When we analyze the impact on kidney function, similar to RAAS blockers, the commencement of treatment with SGLT2 inhibitors is characterized by acute, dose-dependent reductions in eGFR ( up to ~5 mLmin 1 1.73 m 2 ) over several weeks (Heerspink et al, Circulation 2016)