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Andres E, Dali-Youcef N, Serraj K et al

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Unlike most healthy cells, which generate energy primarily through oxidative phosphorylation when oxygen is available, many cancer cells rely heavily on glycolysis even in the presence of oxygen. This phenomenon, known as the Warburg Effect, reflects a metabolic shift that supports rapid cell division by providing both energy and the building blocks required for growth. Because glycolysis depends on a steady supply of NAD+, cancer cells often exhibit higher NAD+ demand to sustain their metabolism. However, this does not mean NAD+ itself causes cancer