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Translational challenges for DAT include model-specific efficacy differences: it enhances anti-CTLA-4 efficacy in B16-OVA melanoma (197), attributed to MC38s low immunogenicity and reduced IFN-I responsivenesshighlighting the need for clinical patient stratification by tumor IFN-I gene signatures (e.g., OAS2/Mx2 expression, 165)

Corrie PG, Bulusu R, Wilson CB, Armstrong G, Bond S, Hardy R, et al

Intracellular DNA replication and long-term survival of pathogenic mycoplasmas

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One is that theres a widespread belief that taking more vitamins than you need just gives you expensive urine, meaning you paid for the supplement and you just peed it out