The pharmacokinetic parameters assessed after single dose administration on Day 1 were: maximum concentration ( C max ), time to C max ( t max ), terminal elimination rate constant ( z , calculated using log-linear regression from at least three points), area under the concentrationtime curve (AUC) until time t (AUC 0t , calculated using the trapezoidal method), AUC extrapolated to infinity (AUC 0 , calculated as AUC 0t + C t / z , where C t is the last measurable drug concentration), proportion of residual AUC extrapolated to infinity (AUC extra , calculated as 100 [ C t / z ]/AUC 0 ), AUC from administration to 12 h on Day 1 (AUC 012 , calculated using the trapezoidal method), t (calculated as ln2/ z ), volume of distribution [ V z , calculated as dose/(AUC 0 z )] and total body clearance (CL t , calculated as dose/AUC 0 ) of NAC in plasma, and total amount excreted until time t (Ae 0t ), fraction excreted until time t (Fe 0t ) and renal clearance (CL r , Ae 0t /AUC 0 ) of NAC in urine
A total of 28 (6%) patients are known to have died at the time of the analysis
A recent study suggestsed that paclitaxel induced sustained activation of mammalian target of rapamycin (mTOR) and downstream MNK-eIF4E signaling pathway to substantially modify the translation efficiency of various ion channels and GPCRs in DRG neurons
, , , -
Shifts in propylthiouracil and methimazole prescribing practices: antithyroid drug use in the United States from 1991 to 2008
