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The AUC and Cmax resulting from administration of IV valproate 500 mg as a single one hour infusion and a single 500 mg dose of divalproex sodium syrup to 17 healthy male volunteers were also equivalent

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However, we hypothesize more complex relationships, such as a compound that is only harmful when it is in combination with other factors (e.g., acute kidney injury caused by the combination of melamine and cyanuric acid 32 , or toxicity caused by a compound in an animal with a specific genetic predisposition)