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A deficiency in AKAP3 may impair sperm motility due to the abnormal accumulation of DNA and RNA metabolites (91)

[73] demonstrated that MK8722 activates the upstream autophagy pathway PI3K/Akt/mTOR, downregulating FASN expression in a dose-dependent manner, and inhibits downstream autophagy by blocking the fusion of autophagosomes and lysosomes, leading to epithelial ovarian cancer cell death

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System xc serves as an amino acid reverse transporter that orchestrates the exchange of extracellular cystine and intracellular glutamate across the cell membrane [77]