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W.et al.2010MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth, 102

Impaired glucose tolerance test, increased oxidative stress, adiposity, and body fat were present to a higher degree in the late intervention in comparison with the early intervention [4]

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Overall Safety and Tolerability Assessment The primary safety conclusion from the comprehensive trial program was unambiguous: AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo