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We have focused in this section on metal-mediated processes since, thus far, they have dominated current strategies, yet it should be noted that other possible strategies exist that exploit non-metal-mediated processes, such as aldol 140 or Wittig chemistry 141 , the use of (formal) cycloaddition chemistry or as the result of a relay from a prior bond-forming event (for example, PictetSpengler)

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GPQC: 1832/2022/XNQC-ATTP GPQC: 2153/2024/XNQC-ATTP

All such findings are observations drawn from controlled preclinical, in-vitro, and animal research and are reported here solely to describe the compound's investigational context