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10.1002/jbt.10052 123 RadhakrishnanE

As discussed earlier in this review, an inflammatory infiltrate mainly composed of monocyte/macrophages (innate) is related to increased oxidative stress and the development of hypertension

JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

Ferroptosis, unlike other forms of cell death that need a direct trigger molecule, occurs as a result of an imbalance between the cellular oxidative media and antioxidant defense, which is fostered by labile reactive iron

In summary, immune evasion, dysregulated inflammation/excessive inflammation, and chronic injury collectively constitute the overall landscape of immune imbalance throughout the entire course of MPP