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Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

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Am J Physiol Gastrointest Liver Physiol 297:G207-214

Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial

A key challenge, however, is maintaining the long-term viability of the encapsulated cells