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Hannenhalli, S

Gallaher, T

M., Gill, D

Nrf2 is found in every cell type with basal level of activation and its level is regulated by 26s proteasomal degradation mediated by E3 ubiquitin ligase (Keap1-Cul3-Rbx) ( Cells are armored with intricate defense system to counter oxidative stress through the Keap1-Nrf2-ARE pathway ( Genomic response by antioxidant signaling inducers suggest NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase (GST) are the two main target genes activated through Nrf2 in T-cell lymphoma (69)