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Last updated on Jan 19, 2026

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B12 also helps break down homocysteine, an amino acid that, if present in high enough amounts, can damage the heart and increase risk of dementia , heart disease, stroke, and osteoporosis, Jen Graham , M.S., R.D.N., a Tallahassee, Florida-based registered dietitian nutritionist with Top Nutrition Coaching, tells Runners World