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Because COX-2 selective inhibitors spare COX-1-mediated platelet aggregation and gastric mucosal protection, they may carry a lower bleeding risk than non-selective agents

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Purification was performed by FLASH chromatography using a PLC 2020 Personal Purification System (Gilson) with a PuriFlash column (130 21 mm, SIHP-JP, 30 m) and a solvent mixture of n-hexane and ethyl acetate (2:1, v/v)

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