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Funding This work was supported by grants from the National Natural Science Foundation of China [81601121, 82401671], Natural Science Foundation of Jiangsu Province [BK20211235, BK20231050], China Postdoctoral Science Foundation [2020M651491], Jiangsu Province Postdoctoral Science Foundation [2020Z037], Six Talent Peaks Project in Jiangsu Province [SZCY-003], Youth Talent Support Project of Jiangsu Province for Science and Technology [JSTJ-2024-370], Medical Development Foundation of Jiangnan University [YXXK20240926003], Fundamental Research Funds for the Central Universities [JUSRP123070]

Some jurisdictions may have stricter COC limits for water resources preservation and should be checked by the designer

We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]

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