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Second, using purified OPC primary cultures, we demonstrate that they can act cell-autonomously in OPCs to promote their differentiation/maturation, in agreement with a recent study showing that folic acid, also involved in folate metabolism, can enhance oligodendrocyte differentiation 88

Consequently, serum iron levels are reduced as a result of reduced iron assimilation and macrophage iron retention, whereas total body iron remains unaffected [72]

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, et al

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