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Yeah, so we're recording a bit in the past and I just got back from the Unimonia conference and oh yeah, it was really fun

This rescue of acetyl-CoA labeling was accompanied by a rescue of labeling in the downstream TCA cycle metabolites citrate and succinate

We hypothesized that carbon flow for glutamate synthesis was markedly affected in the CgCS+CitS strain, and that glutamate overproduction or enhanced citrate uptake induced by CitS may inhibit the conversion of glucose to glutamate

Odegard, Koichi Yuki, Sophia Koutsogiannaki Critical Care.2025;[Epub] CrossRef Effects of antidiabetic medications on the relationship between type 2 diabetes mellitus and cognitive impairment Annalisa Cozza, Chiara Chinig, Elvira Filicetti, Giada Ida Greco, Rosamaria Lappano, Cinzia Marinaro, Lucia Muglia, Luca Soraci, Andrea Corsonello, Fabrizia Lattanzio, Mara Volpentesta Ageing Research Reviews.2025

This reversible disassemblyreconstruction experiment demonstrated convincingly that the cysteine trisulfide bond is an essential cofactor for SQOR catalysis