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It has been reported that only the exo-epoxide effectively interacts with DNA and was at least 500-fold more potent as a mutagen than the endo stereoisomer

While none of the uteri from control mice showed evidence of adenomyosis, we identified advanced disease denoted by deep, adenomyotic lesions in mice with a direct (F1F2) and indirect (F3) in utero TCDD exposure

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Glutathione, meanwhile, is often marketed heavily for "glow" and skin lightening, but the evidence for visible skin-tone change is mixed and dose-dependent, and results vary widely between individuals

In Embodiment 24 of this disclosure are compounds of Formula I, or Embodiments 1-11, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 2 is C(O) aryl