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The lack of a standardized normalization method in microarray techniques, along with the poor correlation between altered miRNA expression profiles and their functionality in cancer as shown in functional assays, necessitates a more precise method to link miRNA with cancer prognosis (180, 181)

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GH was also found to promote an increase in mitochondrial oxidative capacity and abundance of several mitochondrial genes when acutely administered (209) while exogenous administration of IGF-1 was associated with a reduced susceptibility of dystrophic muscles to contraction-induced injury (210)