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2009 RCT documented improvements in mottled hyperpigmentation alongside fine-wrinkle reduction in photoaged skin 10

Candidacy: Who Should Consider Each Peptide

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Treatment Duration and Cycling Treatment duration and cycling follows patterns without evidentiary basis: active phase of 6-12 weeks continuous use followed by 4-8 week breaks

The peptide works through multiple pathways including growth hormone receptor activation, angiogenesis promotion, and fibroblast migration to damaged tissue