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Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis

Most people notice visible improvement in 3 to 6 weeks with consistent use

Lee WJ, Sim HB, Jang YH, et al

The medication already creates substantial caloric deficit through appetite suppression and increased energy expenditure, making additional cardio largely redundant for fat loss while potentially accelerating muscle catabolism